Paul W Hruz Selected Research

HIV Protease Inhibitors

10/2017	Development of GLUT4-selective antagonists for multiple myeloma therapy.
6/2015	In Silico Modeling-based Identification of Glucose Transporter 4 (GLUT4)-selective Inhibitors for Cancer Therapy.
1/2011	HIV protease inhibitors act as competitive inhibitors of the cytoplasmic glucose binding site of GLUTs with differing affinities for GLUT1 and GLUT4.
12/2009	Acipimox, an inhibitor of lipolysis, attenuates atherogenesis in LDLR-null mice treated with HIV protease inhibitor ritonavir.
11/2008	HIV protease inhibitors and insulin resistance: lessons from in-vitro, rodent and healthy human volunteer models.
7/2008	HIV protease inhibitors that block GLUT4 precipitate acute, decompensated heart failure in a mouse model of dilated cardiomyopathy.
12/2005	Direct comparison of the acute in vivo effects of HIV protease inhibitors on peripheral glucose disposal.
12/2004	A structural basis for the acute effects of HIV protease inhibitors on GLUT4 intrinsic activity.
7/2003	HIV protease inhibitors acutely impair glucose-stimulated insulin release.
4/2002	Indinavir induces acute and reversible peripheral insulin resistance in rats.

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Paul W Hruz Research Topics

Disease

16	Insulin Resistance 12/2018 - 04/2002
4	Heart Failure 01/2018 - 07/2008
4	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2018 - 07/2008
3	Malaria 01/2017 - 10/2015
3	Glucose Intolerance 11/2010 - 07/2003
2	Inflammation (Inflammations) 01/2020 - 12/2018
2	Obesity 01/2018 - 08/2009
2	Type 2 Diabetes Mellitus (MODY) 01/2018 - 08/2009
2	Neoplasms (Cancer) 10/2017 - 06/2015
2	Multiple Myeloma 10/2017 - 06/2015
2	Diabetes Mellitus 10/2011 - 11/2008
2	Atherosclerosis 12/2009 - 08/2009
2	HIV Infections (HIV Infection) 01/2006 - 12/2004
2	Lipodystrophy 01/2006 - 04/2002
2	Hyperlipidemias (Hyperlipidemia) 01/2006 - 04/2002
1	Gender Dysphoria 02/2020
1	Non-alcoholic Fatty Liver Disease 01/2020
1	Infections 01/2020
1	Clostridium Infections 01/2020
1	Body Weight (Weight, Body) 01/2020
1	Reperfusion Injury 01/2018
1	Metabolic Diseases (Metabolic Disease) 01/2018
1	Myocardial Ischemia (Ischemic Heart Diseases) 01/2018
1	Overnutrition 01/2018
1	Pathological Protein Aggregation 02/2016
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 06/2015
1	Disease Progression 10/2011
1	Hyperglycemia 10/2011
1	Hypersensitivity (Allergy) 10/2011
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 06/2011
1	Hepatic Insufficiency 12/2010
1	Hypoglycemia (Reactive Hypoglycemia) 12/2010
1	Acquired Immunodeficiency Syndrome (AIDS) 12/2009
1	Dyslipidemias (Dyslipidemia) 08/2009
1	HIV-Associated Lipodystrophy Syndrome 01/2009
1	Cardiovascular Diseases (Cardiovascular Disease) 11/2008
1	Pulmonary Edema 07/2008
1	Cardiomyopathies (Cardiomyopathy) 07/2008
1	Genetic Predisposition to Disease (Genetic Predisposition) 01/2006
1	Insulinoma 07/2003

Drug/Important Bio-Agent (IBA)

18	Glucose (Dextrose)FDA LinkGeneric 12/2018 - 04/2002
10	HIV Protease InhibitorsIBA 10/2017 - 04/2002
7	Ritonavir (Norvir)FDA Link 01/2018 - 12/2006
5	Pharmaceutical PreparationsIBA 10/2015 - 04/2002
4	Insulin (Novolin)FDA Link 10/2011 - 04/2002
3	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 12/2016 - 02/2011
2	CholesterolIBA 01/2020 - 08/2009
2	TrehaloseIBA 01/2020 - 02/2016
2	LipidsIBA 01/2020 - 08/2009
2	Lopinavir FDA Link 10/2015 - 07/2008
2	Glucagon-Like Peptide 1 (GLP 1)IBA 12/2012 - 02/2011
2	Protease Inhibitors (Protease Inhibitor)IBA 01/2009 - 11/2008
1	Gonadal Steroid Hormones (Sex Hormones)IBA 02/2020
1	Gonadotropin-Releasing Hormone (GnRH)FDA Link 02/2020
1	FructoseIBA 01/2020
1	TrehalaseIBA 01/2020
1	CarbohydratesIBA 01/2020
1	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2018
1	Cytostatic AgentsIBA 10/2017
1	Dexamethasone (Maxidex)FDA LinkGeneric 10/2017
1	Melphalan (Alkeran)FDA LinkGeneric 10/2017
1	compound 20IBA 10/2017
1	venetoclaxIBA 10/2017
1	DisaccharidesIBA 02/2016
1	Metformin (Glucophage)FDA LinkGeneric 06/2015
1	Dipeptidyl-Peptidase IV InhibitorsIBA 12/2012
1	saxagliptin FDA Link 12/2012
1	Adenosine Triphosphate (ATP)IBA 10/2011
1	Blood Glucose (Blood Sugar)IBA 10/2011
1	Glyburide (Glibenclamide)FDA LinkGeneric 10/2011
1	Antiviral Agents (Antivirals)IBA 06/2011
1	AdipokinesIBA 06/2011
1	Exenatide (Byetta)FDA Link 02/2011
1	Carbon Tetrachloride (Tetrachloromethane)IBA 12/2010
1	acipimoxIBA 12/2009
1	Deoxyglucose (2 Deoxy D glucose)IBA 08/2009
1	Triglycerides (Triacylglycerol)IBA 08/2009
1	LDL CholesterolIBA 08/2009
1	MyostatinIBA 08/2009
1	Nonesterified Fatty Acids (NEFA)IBA 08/2009
1	Cre recombinaseIBA 07/2008
1	tipranavir FDA Link 12/2006
1	Proteins (Proteins, Gene)FDA Link 01/2006
1	Anti-Retroviral Agents (Antiretroviral Agents)IBA 01/2006
1	Glucose Transporter Type 4IBA 07/2003
1	Indinavir (Crixivan)FDA Link 04/2002

Therapy/Procedure

6	Therapeutics 10/2017 - 04/2002
2	Highly Active Antiretroviral Therapy (HAART) 01/2006 - 07/2003
1	Hepatectomy 12/2010